anxiety – Page 7 – mycolab.ai

The psychedelic-peptide paradox: a hormetic hypothesis

mycolabadmin

This review explores how psychedelic drugs like LSD and psilocybin work through the body’s natural stress-response systems, particularly two brain chemicals called oxytocin and vasopressin. It explains why psychedelics initially cause uncomfortable feelings like nausea and anxiety, but these are followed by improved mood, sociability, and emotional healing. The theory suggests that this initial ‘stress’ response triggers the body’s natural healing mechanisms, similar to how physical exercise makes you uncomfortable initially but builds strength over time.

Sustainable Innovations in Food Microbiology: Fermentation, Biocontrol, and Functional Foods

mycolabadmin

This review explores how microorganisms can make food production more sustainable and healthier. It discusses traditional fermented foods like yogurt and sauerkraut, modern biotechnology techniques to reduce food waste and create natural preservatives, and special food ingredients with beneficial bacteria that support digestive and mental health. The paper shows how applying microbial science could help address global food challenges while meeting consumer demands for natural, safe, and healthy products.

Molecular insights into the modulation of the 5HT 2A receptor by serotonin, psilocin, and the G protein subunit Gqα

mycolabadmin

This study uses computer simulations to understand how psilocin (the active compound in magic mushrooms) and serotonin interact with a brain receptor called 5HT 2A R. The research shows that both molecules prefer to bind to a deeper part of the receptor rather than a shallower area, and that a protein called Gqα is essential for keeping the receptor in its active state. These findings could help scientists develop better medicines for depression and anxiety.

Selective outcome reporting and non-reporting in trials of psychedelic drugs for mental disorders

mycolabadmin

Researchers examined whether studies of three promising psychedelic drugs (esketamine, psilocybin, and MDMA) for treating mental health conditions were reporting their results fairly and completely. They found that nearly 29% of completed trials had no published results, and some studies changed which outcomes they reported on between registration and publication. This selective reporting could make these drugs appear more effective than they actually are.

Nature-themed video intervention may improve cardiovascular safety of psilocybin-assisted therapy for alcohol use disorder

mycolabadmin

Researchers tested whether watching nature videos during psilocybin therapy could improve treatment for alcohol addiction. Twenty participants received psilocybin sessions while either watching nature videos or using standard procedures with eyeshades and music. The study found that nature videos significantly reduced the blood pressure increases that normally occur with psilocybin, while maintaining the same therapeutic benefits for reducing alcohol use and promoting meaningful experiences.

Neural mechanisms underlying psilocybin’s therapeutic potential – the need for preclinical in vivo electrophysiology

mycolabadmin

Psilocybin, the active compound in magic mushrooms, shows promise for treating depression and other mental health conditions. This review examines how psilocybin works in the brain, particularly by affecting brain regions involved in self-reflection and emotion regulation. The authors argue that new brain recording techniques are needed to fully understand how psilocybin produces its beneficial effects, which could help improve treatments for people with severe depression.

“Plants of the Gods” and their hallucinogenic powers in neuropharmacology — A review of two books

mycolabadmin

This review examines two books about plants that have been used in religious and healing rituals across many cultures for their mind-altering properties. The author verifies that the hallucinogenic plants described in Carlos Castaneda’s popular books about a Yaqui sorcerer are accurately portrayed pharmacologically. The review explains how different sacred plants like peyote, certain mushrooms, and nightshade varieties affect the brain through various chemical pathways, while noting their dangers when misused.

Recalled childhood trauma and post-psychedelic trajectories of change in a mixed-methods study

mycolabadmin

This study examined how childhood trauma can resurface during psychedelic experiences and what happens afterward. Researchers surveyed over 600 people who had difficult experiences after using psychedelics, and interviewed 18 of them in detail. They found that trauma surfaced in different ways—some people vividly relived events, others felt intense bodily sensations, and some experienced confusion. About half of participants found healing from the experience, while others struggled with ongoing trauma symptoms or mixed outcomes. The research emphasizes the importance of proper preparation, supportive settings, and follow-up integration work to help people process these experiences safely.

Dietary Intake of Phytochemicals, Gut Microbiota, and Appetite Control

mycolabadmin

This research editorial highlights how plant-based foods rich in phytochemicals can improve gut health by promoting beneficial bacteria growth and supporting communication between the gut and brain. These dietary interventions show promise in helping control appetite, improve metabolism, and reduce the risk of diseases like obesity and type 2 diabetes. The studies suggest that personalized nutrition approaches based on individual microbiome profiles could offer more effective disease prevention and health maintenance strategies.

Chronic pain as an emergent property of a complex system and the potential roles of psychedelic therapies

mycolabadmin

Chronic pain affects millions of people and is often resistant to current treatments. This paper suggests that chronic pain emerges from interconnected biological, psychological, and social factors working together as a complex system. The authors propose that psychedelic-assisted therapies could help by breaking rigid thought and behavior patterns that maintain pain, allowing the brain and mind to reorganize in healthier ways, similar to how mindfulness meditation works but potentially more dramatically.

Disease: anxiety