Disease: allergic asthma

Microfungus Podosphaera fusca and the Fungus-like Organism Peronospora ficariae as Potential Inhalant Allergens in a Mouse Model of Asthma

This study found that two types of plant fungi, Podosphaera fusca and Peronospora ficariae, can trigger asthma-like reactions in mice similar to known allergens. While these fungi produce weaker responses than the standard allergen ovalbumin, they still cause significant inflammation, immune activation, and airway changes. The research suggests these plant parasites should be added to the list of recognized allergens that may trigger respiratory problems in humans.

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Biochemical characteristics of extracts from proallergenic microfungi Erysiphe palczewskii and Erysiphe convolvuli

Researchers studied two types of fungi that cause powdery mildew on plants and can trigger allergies in people who breathe in their spores. They discovered that these fungi contain proteins that act as allergens, including special proteins that help fungi survive stress. The fungi also contain high levels of linoleic acid, a fatty acid that can increase inflammation in the body. This research helps scientists understand why these fungi can cause allergic reactions and could help develop better diagnostic tools for fungal allergies.

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Microfungus Podosphaera fusca and the Fungus-like Organism Peronospora ficariae as Potential Inhalant Allergens in a Mouse Model of Asthma

Researchers studied two types of plant fungi that infect common vegetables and plants to determine if they could cause asthma in mice. They found that both organisms triggered immune responses similar to those caused by known allergens, producing inflammation and asthma-like symptoms. Although their effects were weaker than the reference allergen ovalbumin, both fungi showed significant potential as respiratory allergens. This research suggests these plant parasites should be recognized as possible triggers for asthma and allergic reactions in people.

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Fluconazole worsened lung inflammation, partly through lung microbiome dysbiosis in mice with ovalbumin-induced asthma

Fluconazole is an antifungal medication that works well for treating asthma caused by fungal infections, but may actually worsen asthma from other causes. In mice with allergic asthma, fluconazole killed beneficial bacteria and promoted the growth of harmful bacteria that increased inflammation. This study suggests that fluconazole should only be used for fungal-related asthma and careful monitoring is needed if used in patients with regular asthma.

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