aging – mycolab.ai

Solid-state fermentation as a strategy for improvement of bioactive properties of the plant-based food resources

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This review explains how fermentation—a natural biological process—can enhance the health-promoting compounds in plant-based foods. By using specific fungi and bacteria on solid plant materials, scientists can increase beneficial antioxidants and proteins that may help prevent chronic diseases. This method is more environmentally friendly and cost-effective than traditional extraction techniques, making nutritious plant foods even healthier.

Extraction Optimization and Bioactivity of Polysaccharides from Ganoderma leucocontextum Spores

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Researchers developed an improved method to extract beneficial polysaccharides from Ganoderma leucocontextum (white Ganoderma), a rare mushroom from the Tibetan plateau. The extracted compound GLSP-A1 showed strong anti-inflammatory effects by reducing inflammatory markers and reduced signs of aging in test organisms by decreasing harmful reactive oxygen species and cellular aging pigments. This work suggests the mushroom polysaccharide could potentially be used in dietary supplements to help slow aging.

Biological Characteristics, Domesticated Cultivation Protocol, Antioxidant Activity, and Protective Effects against Cellular Oxidative Stress of an Underutilized Medicinal Mushroom: Fomitopsis palustris

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Researchers successfully grew and studied Fomitopsis palustris, a medicinal mushroom, in laboratory conditions. They discovered that the mushroom contains beneficial compounds that protect cells from damage caused by harmful free radicals. The polysaccharides extracted from the mushroom boosted the cells’ natural defense systems and reduced oxidative stress markers, suggesting potential health benefits for treating age-related and degenerative diseases.

Investigating the Neuroprotective, Hepatoprotective, and Antimicrobial Effects of Mushroom Extracts

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This study examined four types of edible mushrooms to see if they could protect against aging and fight harmful bacteria. Researchers gave mice an aging-inducing substance and then treated them with mushroom extracts. The mushrooms, particularly Lion’s Mane (Hericium erinaceus), helped prevent brain and liver damage, reduced inflammation, and showed antibacterial effects against multiple bacterial strains. These findings suggest mushrooms could be useful natural supplements to promote health and combat age-related decline.

Evaluation of Two Different Treatments for Larch Logs as Substrates to Cultivate Ganoderma tsugae in the Forest

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This study compared growing the medicinal mushroom Ganoderma tsugae on sterilized versus non-sterilized larch wood in a forest setting. Researchers found that non-sterilized wood actually produced mushrooms with higher levels of beneficial compounds like triterpenoids and polysaccharides, while requiring less processing and cost. These findings suggest that farmers can use a simpler, less expensive cultivation method while still producing high-quality medicinal mushrooms.

Soil microorganism colonization influenced the growth and secondary metabolite accumulation of Bletilla striata (Thunb.) Rchb. F.

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Chinese ground orchid (Bletilla striata) is a medicinal plant whose growth and medicinal compound production depend heavily on soil microorganisms. Researchers found that different soil types harbor different beneficial microbes: sandy loam soils boost plant growth, while sandy clay soils increase medicinal compound concentration. Specific microbes colonize different plant parts, with some promoting growth in roots and tubers, while others enhance the production of militarine, a compound with potential anti-aging and cognitive benefits.

Multi-omics analysis of Taiwanofungus gaoligongensis: effects of different cultivation methods on secondary metabolites

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Researchers studied how different growing methods affect the medicinal compounds produced by Taiwanofungus gaoligongensis, a rare fungus. By growing the fungus on different substrates including wood from specific trees, they found that certain growing methods produced much higher levels of beneficial compounds like antcins that have anti-cancer and anti-inflammatory properties. They also identified which genes control the production of these compounds, which could help improve cultivation methods to make the fungus more medicinally valuable.

Biological Characteristics and Domestication of Dichomitus squalens and the Antioxidant Activity of Its Cultivated Fruiting Bodies

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Researchers cultivated a type of fungus called Dichomitus squalens and extracted beneficial compounds called polysaccharides from its fruiting bodies. These polysaccharides showed strong antioxidant properties, meaning they can help protect cells from damage caused by harmful free radicals. The study identified the best growing conditions for this fungus and developed methods for farming it, suggesting it could become a natural source of antioxidants for health applications.

Anoectochilus roxburghii Extract Extends the Lifespan of Caenorhabditis elegans through Activating the daf-16/FoxO Pathway

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Researchers studied a traditional Asian orchid plant (Anoectochilus roxburghii) and found it can extend the lifespan of laboratory worms by about 16% and help them resist stress from UV light and heat. The plant works by activating a specific genetic pathway that increases the worm’s natural antioxidant defenses, protecting cells from damage. These findings suggest the plant could potentially be developed into anti-aging products for humans.

Biological Characteristics, Artificial Domestication Conditions Optimization, and Bioactive Components of Beauveria caledonica

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Scientists successfully grew Beauveria caledonica mushrooms in a laboratory for the first time using wheat and rice as growing media. They identified the best growing conditions and found that these mushrooms contain beneficial compounds like polysaccharides and adenosine, which may have health benefits similar to traditional medicinal Cordyceps. The adenosine content was significantly higher than what is required by Chinese pharmacopoeia standards, suggesting these cultivated mushrooms could have strong medicinal value.

Disease: aging