Disease: age spots

Novel tyrosinase-inhibitory peptides derived from Locusta migratoria protein hydrolysates: Preparation, identification and molecular docking analysis

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Scientists have discovered that peptides from locusts can effectively inhibit tyrosinase, an enzyme responsible for skin pigmentation. These peptide extracts showed strong ability to prevent melanin production, comparable to existing skin-whitening agents but with much lower toxicity to normal cells. The research identified over 1100 different peptide sequences that could be useful in cosmetic and pharmaceutical products for treating age spots, freckles, and other pigmentation issues.

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Synthesis and biological assessment of novel 4H-chromene-3-carbonitrile derivatives as tyrosinase inhibitors

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Researchers developed new chemical compounds that can block tyrosinase, an enzyme responsible for producing excessive skin pigment that causes dark spots and discoloration. The most effective compound (6f) works better than kojic acid, a commonly used skin-lightening ingredient, and could lead to safer treatments for hyperpigmentation and related skin conditions. Computer simulations showed that one form of the compound fits better into the enzyme’s active site, making it more effective at preventing melanin production.

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Biological and Cheminformatics Studies of Newly Designed Triazole Based Derivatives as Potent Inhibitors against Mushroom Tyrosinase

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Researchers developed new chemical compounds based on triazole structures to inhibit tyrosinase, an enzyme that produces melanin in skin. One compound (9h) proved particularly effective at blocking this enzyme, working 170 times better than the standard drug kojic acid. Computer modeling showed how this compound fits into the enzyme’s active site. These findings could lead to safer and more effective treatments for skin discoloration disorders like melasma and age spots.

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