Disease: age-related cognitive decline

Fungal Bioactive Compounds as Emerging Therapeutic Options for Age-Related Neurodegenerative Disorders

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Mushrooms contain special compounds that may help protect our brains as we age. These fungal compounds fight inflammation, reduce harmful free radicals, and help clear out damaged cellular parts—all things that slow down brain aging and diseases like Alzheimer’s and Parkinson’s. While the research looks very promising in lab and animal studies, scientists still need to figure out how to make these compounds work better in the human body and prove they’re safe and effective in patients.

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Investigating the Neuroprotective, Hepatoprotective, and Antimicrobial Effects of Mushroom Extracts

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This study examined four types of edible mushrooms to see if they could protect against aging and fight harmful bacteria. Researchers gave mice an aging-inducing substance and then treated them with mushroom extracts. The mushrooms, particularly Lion’s Mane (Hericium erinaceus), helped prevent brain and liver damage, reduced inflammation, and showed antibacterial effects against multiple bacterial strains. These findings suggest mushrooms could be useful natural supplements to promote health and combat age-related decline.

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Glutamate-specific gene linked to human brain evolution enhances synaptic plasticity and cognitive processes

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Scientists discovered that a human gene called GLUD2, which evolved as our brains expanded, makes synapses stronger and more plastic through a lactate-dependent process. When they added this gene to mice, the animals showed improved memory, better learning ability, and stronger brain connections. This research suggests that GLUD2 played a key role in the evolution of human intelligence by enhancing the brain’s ability to form new neural connections and adapt to new information.

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Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity

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Scientists discovered that a protein called TIMP2, which is naturally higher in young blood, plays a crucial role in maintaining brain memory and learning ability. Using laboratory mice, they found that TIMP2 helps keep the brain’s cellular environment flexible by controlling the buildup of structural proteins around nerve connections. Without adequate TIMP2, the brain develops more rigid connections that interfere with forming new memories and creating new brain cells, mimicking changes seen in aging and cognitive decline.

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