Disease: addictive disorders

Horizontal gene cluster transfer increased hallucinogenic mushroom diversity

Scientists discovered that distantly related hallucinogenic mushrooms produce psilocybin, the psychoactive compound in magic mushrooms, through a shared set of genes that were likely transferred between species living in similar environments like dung and decaying wood. By sequencing the genomes of three different hallucinogenic mushroom species, researchers found nearly identical gene clusters responsible for making psilocybin, and evidence showing these genes jumped between unrelated fungal lineages. This discovery suggests that fungi in dung and wood environments may be rich sources of other bioactive compounds with potential medical applications.

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Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience

Researchers studied how DMT affects the brain’s ability to switch between different activity patterns. Using simultaneous brain imaging (fMRI) and electrical recordings (EEG), they found that DMT makes these transitions easier and less energy-intensive. The effects occurred primarily in brain regions with high levels of serotonin 2a receptors and were accompanied by increased complexity of brain signals and stronger subjective drug effects.

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