Bioactive Compound: Lysergic acid diethylamide (LSD)

Lysergic Acid Diethylamide (LSD) and the Heart: Exploring the Potential Impacts of LSD on Cardiovascular Function

This review examines how LSD affects the heart and blood vessels. While some evidence suggests LSD might protect against heart disease by reducing inflammation and blood clots, acute use can dangerously raise heart rate and blood pressure, and cause blood vessel constriction. Regular low-dose use raises concerns about potential valve damage. More research is needed to understand the full cardiovascular safety of LSD before it can be considered for medical use.

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Psilocybin-assisted therapy for severe alcohol use disorder: protocol for a double-blind, randomized, placebo-controlled, 7-month parallel-group phase II superiority trial

This study tests whether psilocybin (the active compound in magic mushrooms) combined with therapy can help people with severe alcohol addiction reduce drinking. Participants receive either a high or low dose of psilocybin during a guided session as part of a hospital rehabilitation program. The researchers will measure changes in drinking behavior, mood, anxiety, and brain function to determine if this treatment works better than current options.

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Effects of classical psychedelics on implicit and explicit emotional empathy and cognitive empathy: a meta-analysis of MET task

This study compiled data from multiple research studies to understand how classical psychedelics like LSD, psilocybin, and ayahuasca affect empathy—the ability to understand and share others’ feelings. The findings show these substances significantly increase emotional empathy, helping people feel more connected to others’ emotions. However, they don’t appear to affect cognitive empathy, which is the mental ability to understand what others are thinking. These results suggest psychedelics may have therapeutic potential for improving social connection and emotional understanding.

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