Bioactive Compound: α-glucans

Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials

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This comprehensive review examines how medicinal mushrooms contain natural compounds that can boost immune function, fight cancer cells, reduce inflammation, and protect nerve cells. Different mushroom species like reishi, shiitake, and maitake contain various active substances such as beta-glucans and triterpenes that work through multiple biological pathways. While laboratory and animal studies show promising results, more human clinical trials are needed to confirm effectiveness and establish safe dosing guidelines.

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Characterisation and Hypolipidaemic Effects of Tlayudas, Widely Consumed Tortillas, Containing Ganoderma lucidum Extracts on an In Vivo Model of Hypercholesterolaemia

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Researchers created an improved version of tlayudas, a traditional Mexican tortilla, by adding extracts from the medicinal mushroom Ganoderma lucidum. When mice were fed a high-cholesterol diet with these enhanced tlayudas, they experienced significant reductions in cholesterol and triglycerides comparable to or better than pharmaceutical treatments. These functional foods could help Mexican communities reduce their risk of heart disease and other health problems related to diet.

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The Effect of Green Extraction Technologies on the Chemical Composition of Medicinal Chaga Mushroom Extracts

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Researchers compared three environmentally friendly methods for extracting beneficial compounds from Chaga mushrooms collected from Serbia and Mongolia. The study found that heating mushroom material with water under pressure (subcritical water extraction) was the most effective at extracting important compounds like glucans and phenols. These findings help the mushroom supplement industry choose the best extraction method based on which compounds they want to produce.

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Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake

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Researchers studied a combination of three medicinal mushroom extracts to see if they work better together than separately. They tested this formula on human immune cells called macrophages and found that the combination was significantly more powerful at boosting immune responses than any single mushroom extract alone. This synergistic effect means the three mushrooms enhance each other’s immune-stimulating properties, suggesting this formula combination could have potential therapeutic benefits for immune support.

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