Anti-Therapeutic Action: VBNC cells represent a challenge for antifungal therapy due to reduced metabolic activity and potential resistance mechanisms

Immunometabolic reprogramming in macrophages infected with active and dormant Cryptococcus neoformans: differential modulation of respiration, glycolysis, and fatty acid utilization

Researchers discovered that when fungal yeast cells enter a dormant state inside immune cells, they trigger different metabolic changes compared to actively growing yeast. While active yeast pushes immune cells to work harder metabolically, dormant yeast causes minimal stress but increases fat uptake by immune cells. This difference may explain how some fungal infections can remain hidden in the body for long periods without causing symptoms.

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