Anti-Therapeutic Action: treatment failure

Cracks in the Curriculum: The Hidden Deficiencies in Fungal Disease Coverage in Medical Books

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Medical textbooks used to train doctors contain significant gaps in their coverage of fungal infections, which cause millions of deaths annually. While infectious disease textbooks provide better information than general internal medicine textbooks, all of them fall short in covering important topics like diagnosis methods and prevention strategies. The study found that doctors and students relying solely on these textbooks may not have adequate knowledge to properly diagnose and treat fungal infections, which could impact patient care outcomes.

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Azole Resistance in Aspergillus Species Isolated from Clinical Samples: A Nine-Year Single-Center Study in Turkey (2015–2023)

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This study examined azole antifungal resistance in fungal infections from a Turkish hospital over nine years. Researchers tested 200 Aspergillus fungal isolates and found that 7% showed resistance to azole medications, with 11% of Aspergillus fumigatus showing resistance. The findings highlight the ongoing challenge of drug-resistant fungal infections and the importance of monitoring resistance patterns to improve treatment decisions for serious fungal infections.

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Investigating the Increasing Azole Resistance in Candida Infections Among Critically Ill Patients: Experience From a Tertiary-Level Setup in North India

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This study tracked the increase in drug-resistant yeast infections in hospitalized patients in India from 2023 to 2025. The researchers found that common antifungal medications like fluconazole are becoming less effective, with resistance rates nearly doubling over the study period. The good news is that newer antifungal drugs called echinocandins remained highly effective. The findings highlight the need for better infection control measures and more careful use of antifungal medications.

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Superficial Fungal Infections in Children—What Do We Know?

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Fungal infections of the skin, hair, and nails are increasingly common in children worldwide, especially in warm, humid climates and in crowded living conditions. These infections are caused by germs that live on the skin and can spread through contact with infected people or animals. Children are particularly vulnerable due to their developing immune systems, but most infections are treatable with topical creams or oral medications, with terbinafine being the most effective option currently available.

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Dermatophyte Treatment Failure: A Rapid Global Response to an Emerging Global Health Issue

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Fungal skin infections affect nearly a billion people worldwide and are becoming increasingly difficult to treat due to growing resistance to common antifungal medications. A new species of fungus called T. indotineae, particularly resistant to the popular antifungal drug terbinafine, is spreading globally from India. To combat this emerging health crisis, doctors and health organizations are working together to create global registries and surveillance programs to track resistant infections and develop better treatment strategies.

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Insights into the structure, function, and impact of Candida albicans UPC2 gene on azole resistance; a mini-review

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Candida albicans is a common fungal infection that doctors treat with azole medications, but the fungus is increasingly developing resistance to these drugs. Scientists have discovered that a gene called UPC2 plays a key role in this resistance by controlling the production of enzymes that help the fungus survive azole treatment. Understanding how UPC2 works could help develop new strategies to overcome drug-resistant fungal infections.

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