Anti-Therapeutic Action: Terbinafine resistance due to SQLE gene mutations

Emergence of resistant dermatophytosis caused by Trichophyton indotineae: First case series in Thailand

Researchers in Thailand have identified the first cases of a new resistant fungal skin infection caused by Trichophyton indotineae. This fungus is resistant to a commonly used antifungal drug called terbinafine and causes persistent skin rashes on various body parts. The study describes five patients whose infections were finally identified through genetic testing and who responded well to alternative antifungal treatment with itraconazole. This discovery suggests the fungus is now spreading in Thailand and doctors should watch for it.

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qPCR-Based Molecular Detection of Trichophyton indotineae by Targeting Divergent Sequences

Trichophyton indotineae is a dangerous fungal infection that causes ringworm and is increasingly resistant to common antifungal treatments. Scientists developed a rapid blood test-like diagnostic tool called qPCR that can accurately identify this specific fungus in less than 2 hours for just a few dollars. The test was created by comparing the genetic codes of different fungal species to find unique fingerprints that distinguish T. indotineae from similar-looking fungi.

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