Anti-Therapeutic Action: terbinafine resistance

Emerging antifungal resistance in Trichophyton mentagrophytes: insights from susceptibility profiling and genetic mutation analysis

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This study examined how common skin fungal infections caused by Trichophyton species are becoming resistant to standard antifungal treatments. Researchers tested 131 fungal isolates from China and analyzed their resistance genes to understand why some strains no longer respond to terbinafine and other antifungal drugs. They found that certain genetic mutations, particularly in the SQLE gene, make these fungi resistant to treatment and that different species have different resistance patterns. These findings help doctors better choose treatments and guide the development of new antifungal medications.

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Emergence of resistant dermatophytosis caused by Trichophyton indotineae: First case series in Thailand

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Researchers in Thailand have identified five patients with a difficult-to-treat fungal skin infection caused by Trichophyton indotineae, a type of dermatophyte that resists the commonly used antifungal drug terbinafine. This is the first time this resistant fungus has been detected in Thailand. The team developed a simple, inexpensive test using urease to help identify these resistant infections more easily. Patients responded well to the antifungal drug itraconazole after other treatments failed.

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Emergence of resistant dermatophytosis caused by Trichophyton indotineae: First case series in Thailand

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Researchers in Thailand identified five patients with a new type of fungal skin infection caused by Trichophyton indotineae, a species that resists the common antifungal drug terbinafine. These infections appeared as rashes on various parts of the body and required treatment with alternative medications like itraconazole. The findings represent the first confirmed cases in Thailand and suggest this resistant fungus may be spreading globally. The study also showed that a simple urease test could help doctors identify this resistant strain quickly without waiting for complex genetic testing.

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First case report of tinea corporis caused by Trichophyton indotineae in Latin America

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A 21-year-old woman in Argentina developed a persistent skin infection caused by a fungus called Trichophyton indotineae, likely acquired during travel to Mexico. The infection did not respond to common antifungal medications like terbinafine, but responded well to treatment with a special formulation of itraconazole that was completely effective within four weeks. This case represents the first documented occurrence of this emerging fungal pathogen in Latin America and highlights the importance of molecular identification when standard treatments fail.

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Integrating Machine Learning and Molecular Methods for Trichophyton indotineae Identification and Resistance Profiling Using MALDI-TOF Spectra

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A new type of fungus called Trichophyton indotineae is causing stubborn skin infections that don’t respond well to standard antifungal treatments. Researchers used advanced laboratory techniques combined with computer analysis to better identify this fungus from MALDI-TOF spectra, which is a quick fingerprinting method for microorganisms. The study showed that machine learning could accurately distinguish this problematic fungus from similar species and found specific markers that could help clinics detect it faster, potentially improving patient treatment outcomes.

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Computational analysis of missense mutations in squalene epoxidase associated with terbinafine resistance in clinically reported dermatophytes

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Certain fungal skin infections are becoming resistant to terbinafine, a common antifungal medication, due to genetic mutations in an enzyme called squalene epoxidase. Using computer models and analysis tools, researchers identified which mutations most strongly reduce the drug’s effectiveness and where the protein changes occur. Four specific mutations were found to prevent terbinafine from binding to its target, offering insights that could help develop better antifungal treatments.

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