Anti-Therapeutic Action: terbinafine

Emergence of resistant dermatophytosis caused by Trichophyton indotineae: First case series in Thailand

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Researchers in Thailand have identified the first cases of a new resistant fungal skin infection caused by Trichophyton indotineae. This fungus is resistant to a commonly used antifungal drug called terbinafine and causes persistent skin rashes on various body parts. The study describes five patients whose infections were finally identified through genetic testing and who responded well to alternative antifungal treatment with itraconazole. This discovery suggests the fungus is now spreading in Thailand and doctors should watch for it.

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Masquerading Yeast: A Case Report of Lomentospora prolificans Fungemia With a Diagnostic Twist

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This case describes a patient with blood cancer who developed a rare and deadly mold infection called Lomentospora prolificans while receiving cancer treatment. The infection was difficult to diagnose initially because the fungal structures looked similar to yeast under the microscope, and a molecular test gave a false positive result for a different fungus. Unfortunately, the infection was resistant to all available antifungal medications and the patient died.

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Mucor germinans, a novel dimorphic species resembling Paracoccidioides in a clinical sample: questions on ecological strategy

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Researchers discovered a new fungus called Mucor germinans that infected a cancer patient’s lungs and appeared as yeast cells rather than the typical thread-like fungal structures. This is unusual because Mucor infections normally show filamentous hyphae, and the yeast-like appearance made it look like a different fungus, potentially delaying correct diagnosis and treatment. The study shows that this fungus can change forms depending on temperature and other conditions, and identifying it requires checking for multiple nuclei in the cells to distinguish it from other similar-looking yeasts.

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Mucor germinans, a novel dimorphic species resembling Paracoccidioides in a clinical sample: questions on ecological strategy

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Researchers identified a new fungal species called Mucor germinans from a patient with Burkitt lymphoma that can switch between filamentous and yeast-like forms. This is unusual because Mucor species are typically identified by their thread-like filaments, not budding yeast cells. The yeast form appeared at body temperature and resembled a different fungus called Paracoccidioides, potentially causing misdiagnosis. The discovery emphasizes the importance of recognizing that some Mucor infections may present with yeast-like cells and highlights the need for rapid, accurate identification to guide appropriate antifungal treatment.

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