Anti-Therapeutic Action: substance use disorders

PolDrugs 2025: results of the third edition of the nationwide study on psychoactive substance use in the context of psychiatry and harm reduction

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This Polish study surveyed nearly 2,500 recreational drug users about their substance use patterns and mental health. The survey found that marijuana is the most commonly used illicit drug, but worryingly, most users don’t test what they’re taking or measure doses carefully. The study also revealed increasing use of mephedrone and other stimulants that are sending more people to hospitals, while interest in psychedelics is declining. Importantly, more people are now seeing psychiatrists and being honest about their drug use.

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A taxonomy of regulatory and policy matters relevant to psychedelic-assisted therapy in Australia

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Australia has recently approved psilocybin and MDMA for treating severe depression and PTSD when used with professional therapy support. This paper creates a comprehensive guide outlining all the regulatory, professional, and safety considerations needed to safely deliver these treatments in clinical settings. The researchers interviewed 11 experts and reviewed existing research to identify 102 specific matters that need clear guidelines, such as what qualifications therapists need, where treatments can be delivered, how patients should be screened, and what safety measures are essential.

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Psilocybin-assisted massed cognitive processing therapy for chronic posttraumatic stress disorder: Protocol for an open-label pilot feasibility trial

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This study tests whether psilocybin (a psychedelic compound) combined with intensive therapy can help treat chronic PTSD better than therapy alone. Fifteen patients with PTSD will receive one dose of psilocybin alongside 12 therapy sessions completed over a single week. Researchers will track feasibility, safety, symptom improvements, and use wearable devices to monitor physiological changes. The results will help determine whether larger trials should test this innovative combination therapy.

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