Anti-Therapeutic Action: sexual dysfunction

Molecular Mechanisms of Emerging Antidepressant Strategies: From Ketamine to Neuromodulation

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Depression is a serious mental health condition affecting over 300 million people worldwide, with many patients not responding well to standard antidepressants. This review examines both traditional antidepressants like SSRIs and exciting new treatments including ketamine and psilocybin, as well as brain stimulation techniques. The key finding is that different treatments work through similar mechanisms—all ultimately enhancing brain cell connections and reducing inflammation—suggesting that combining different approaches might work better than single therapies.

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Synthesis and bioactivity of psilocybin analogues containing a stable carbon–phosphorus bond

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Researchers created new chemical versions of psilocybin (the active compound in magic mushrooms) that cannot be broken down by the body’s natural enzymes in the same way. They tested these new compounds to see if they could help with depression and anxiety by targeting specific brain receptors. The best compound worked well on the intended brain receptors but importantly showed less activity on a heart-related receptor, potentially making it safer than natural psilocybin.

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Specific Foods Associated with Depressive Symptoms among Young Adults and Their Bioactive Effects

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This research examined how specific everyday foods like milk, eggs, bananas, oranges, sweet potatoes, mushrooms, and kimchi may help reduce depression symptoms in young adults. The study found that people eating more of these foods had significantly lower rates of depression. These foods contain natural compounds like vitamins, minerals, and antioxidants that support brain health and mood regulation. While more research is needed, the findings suggest that dietary choices could be an important part of managing depression.

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