Anti-Therapeutic Action: proinflammatory effects

The Gut Mycobiome for Precision Medicine

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This comprehensive review explores how fungi in our gut play important roles in our health and disease. While fungi make up only a tiny fraction of our gut microbiota, they have outsized effects on conditions like diabetes, inflammatory bowel disease, and even certain cancers. The review discusses how scientists study these fungi and how understanding individual fungal profiles could lead to personalized medical treatments tailored to each person’s unique microbial makeup.

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Microfungus Podosphaera fusca and the Fungus-like Organism Peronospora ficariae as Potential Inhalant Allergens in a Mouse Model of Asthma

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Scientists studied two fungi that infect plants to see if they could cause asthma-like reactions in mice. They found that these fungi triggered inflammatory responses and produced antibodies similar to other known allergens. While not as potent as ovalbumin (a common test allergen), these plant-infecting fungi showed potential as respiratory allergens that may affect people exposed to them.

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Microfungus Podosphaera fusca and the Fungus-like Organism Peronospora ficariae as Potential Inhalant Allergens in a Mouse Model of Asthma

mycolabadmin

This study found that two types of plant fungi, Podosphaera fusca and Peronospora ficariae, can trigger asthma-like reactions in mice similar to known allergens. While these fungi produce weaker responses than the standard allergen ovalbumin, they still cause significant inflammation, immune activation, and airway changes. The research suggests these plant parasites should be added to the list of recognized allergens that may trigger respiratory problems in humans.

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