A 69-year-old woman with breast cancer developed a skin infection caused by a rare fungus called Cladophialophora boppii while taking dexamethasone for cancer treatment. Doctors diagnosed the infection through skin biopsy and fungal testing, then removed the infected area surgically. After three weeks of antifungal medication (itraconazole), the infection cleared completely and did not return during four months of follow-up. This case suggests that surgery combined with short-term antifungal treatment may be sufficient for this type of infection.