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Therapeutic Potential of Bioactive Compounds in Edible Mushroom-Derived Extracellular Vesicles: Isolation and Characterization of EVs from Pleurotus eryngii

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Scientists have isolated and studied tiny capsule-like particles called extracellular vesicles from the oyster mushroom Pleurotus eryngii. These vesicles, which are naturally produced by the mushroom, contain beneficial compounds like antioxidants that help protect cells from damage. The researchers found that vesicles from mushroom mycelium (the root-like part) were of higher quality and had stronger antioxidant effects than those from the fruiting body. These findings suggest that mushroom-derived vesicles could potentially be developed into health supplements or therapeutic treatments.

Different Symbiotic Species of Armillaria Affect the Yield and Active Compound Contents of Polyporus umbellatus

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Polyporus umbellatus is a medicinal mushroom used in traditional Chinese medicine for treating water retention and swelling. This study found that the type of symbiotic fungus (Armillaria species) growing with the mushroom significantly affects both how much mushroom is produced and the amounts of beneficial compounds it contains. Among three Armillaria species tested, A. gallica produced mushrooms with the highest yields and the most polysaccharides, making it the best choice for cultivation.

Multi-omics analysis of Taiwanofungus gaoligongensis: effects of different cultivation methods on secondary metabolites

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This study examined how different growing methods affect the medicinal compounds found in Taiwanofungus gaoligongensis, a rare Chinese medicinal fungus. Researchers discovered that growing this fungus on wood substrates from specific trees significantly increased production of beneficial compounds like antcins and antrodin C, which have anti-cancer and anti-inflammatory properties. By analyzing gene expression patterns, they identified key genes and regulatory mechanisms that control the production of these medicinal compounds, suggesting ways to improve cultivation methods for better medicinal value.

Microbe Profile: Streptomyces formicae KY5: an ANT-ibiotic factory

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Scientists have discovered a special bacterium called Streptomyces formicae that lives in ant nests and produces powerful antibiotics. This bacterium makes formicamycins, which can kill dangerous bacteria like methicillin-resistant Staphylococcus aureus that resists many common antibiotics. Using advanced genetic tools, researchers can modify this bacterium to unlock hidden antibiotic-producing pathways, potentially leading to new medicines to fight drug-resistant infections.

Isolation, purification, and structural elucidation of Stropharia rugosoannulata polysaccharides with hypolipidemic effect

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Scientists extracted and studied a polysaccharide from wine cap mushrooms that shows promise for lowering cholesterol and protecting the liver. The compound, called SRF-3, has a complex sugar structure and works by binding to cholesterol and bile acids, helping the body eliminate them. Testing in laboratory conditions showed it has strong antioxidant properties and can reduce fat accumulation in liver cells, suggesting potential use as a natural supplement for managing high cholesterol.

The green shield: Trichoderma’s role in sustainable agriculture against soil-borne fungal threats

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This research shows that Trichoderma fungi naturally found in soil can protect plants from harmful fungal diseases. Scientists isolated two types of Trichoderma from soil in the Kashmir region and tested them against 12 different disease-causing fungi. The results showed that these beneficial fungi successfully stopped the growth of harmful pathogens, offering a natural and environmentally safe alternative to chemical pesticides for protecting crops.

Effects of Natural Polysaccharides on the Gut Microbiota Related to Human Metabolic Health

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Natural plant and organism sugars called polysaccharides can improve your gut health by feeding beneficial bacteria and strengthening your intestinal barrier. These compounds help prevent diseases like obesity, diabetes, and inflammatory bowel disease by changing the types of bacteria in your gut and producing helpful substances. Polysaccharides come from common foods like mushrooms, seaweed, berries, and vegetables, making them potential natural treatments for various health conditions.

Evaluation of the Effects of Epicoccum nigrum on the Olive Fungal Pathogens Verticillium dahliae and Colletotrichum acutatum by 1H NMR-Based Metabolic Profiling

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Researchers studied how a beneficial fungus called Epicoccum nigrum can fight two harmful fungi that damage olive trees. Using advanced chemical analysis called NMR spectroscopy, they discovered that when the beneficial fungus encounters disease-causing pathogens, it changes its metabolism and produces compounds that stress the harmful fungi. This study suggests that Epicoccum nigrum could be a natural, environmentally-friendly alternative to chemical fungicides for protecting olive crops.

Novel chia (Salvia Hispanica L.) residue-based substrate formulations for oyster mushroom (Pleurotus ostreatus) cultivation

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Researchers discovered that leftover plant material from chia seed production can be used to grow oyster mushrooms with excellent nutritional value. When chia residues were combined with rice straw in the right proportions, they produced mushrooms with higher protein content, more beneficial compounds, and better yields than traditional growing methods. This finding helps solve two problems at once: it creates a valuable use for chia farming waste while producing highly nutritious mushrooms for human consumption.

The glycolipid flocculosin-A from the fungus Anthracocystis flocculosa, or how to deal with cotton-wool-like crystals

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Scientists successfully determined the three-dimensional structure of flocculosin-A, a powerful antifungal compound produced by a fungus called Anthracocystis flocculosa. The main challenge was that the compound naturally forms very thin, needle-like crystals unsuitable for analysis. By using a special cooling and heating cycle, researchers were able to grow better crystals and use X-ray diffraction to reveal the compound’s complete molecular structure, which contains a sugar backbone connected to two fatty acid chains with specific arrangements.

Anti-Therapeutic Action: None mentioned