Anti-Therapeutic Action: Neurotoxicity

Diversity and functions of fungal VOCs with special reference to the multiple bioactivities of the mushroom alcohol

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Fungi release various volatile compounds (VOCs) that have different effects on organisms and the environment. The most notable fungal VOC is 1-octen-3-ol, also called mushroom alcohol, which gives mushrooms their distinctive smell. This compound can inhibit fungal growth, repel insects, and help control plant diseases, but at high concentrations it may be toxic to humans and trigger immune responses. Scientists use fruit flies as a model to study how these fungal compounds affect health.

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Scoping Review: The Role of Psychedelics in the Management of Chronic Pain

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This review examines how psychedelic drugs like LSD and psilocybin might help treat chronic pain conditions such as cluster headaches and phantom limb pain. The researchers found nine studies suggesting these substances could reduce pain by affecting serotonin receptors in the brain. While early results are promising, more rigorous clinical trials are needed before these drugs can become standard pain treatments. The authors note that strict legal restrictions on psychedelics currently limit research opportunities.

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Pharmaceutical Pollution in Aquatic Environments: A Concise Review of Environmental Impacts and Bioremediation Systems

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Medications we take for health are ending up in our water supplies in significant amounts because standard water treatment plants cannot remove them effectively. These pharmaceutical residues are harming wildlife and aquatic ecosystems, causing problems like population declines in birds, developmental issues in fish, and the spread of antibiotic resistance. Scientists are developing new bioremediation technologies, particularly using fungi and mycoremediation, to better remove these drugs from wastewater before they reach our water bodies.

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Pore-Forming Cardiotoxin VVA2 (Volvatoxin A2) Variant I82E/L86K Is an Atypical Duplex-Specific Nuclease

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Researchers discovered that a toxic protein from edible mushrooms called VVA2 has a hidden ability to cut double-stranded DNA. When modified to remove its toxic effects, this protein became a powerful DNA-cutting enzyme that works best at warm temperatures and requires specific metal ions to function. This discovery could have practical applications in DNA research and diagnostic testing.

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