Anti-Therapeutic Action: Mycotoxin contamination

Fungi: Pioneers of chemical creativity – Techniques and strategies to uncover fungal chemistry

This review explores how fungi produce remarkable chemical compounds that have been transformed into important medicines for over a century. Starting with penicillin in the 1940s, scientists have discovered dozens of fungal-derived drugs used to treat infections, prevent organ rejection, lower cholesterol, and fight cancer. Modern technology now allows researchers to discover and analyze these compounds much faster and with smaller samples than ever before.

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Comparative genome analysis of patulin-producing Penicillium paneum OM1 isolated from pears

Scientists sequenced the genome of a pear fungus called Penicillium paneum that produces patulin, a toxic compound found in moldy apples and pears. By analyzing its genetic blueprint, researchers identified 33 different toxin-producing gene clusters, with special focus on the 15 genes responsible for patulin production. The findings reveal which genes P. paneum uses to make patulin and how they compare to other fungal species, potentially helping develop better ways to prevent patulin contamination in fruit and fruit products.

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The palmitoyl-CoA ligase Fum16 is part of a Fusarium verticillioides fumonisin subcluster involved in self-protection

Fusarium verticillioides is a fungus that produces fumonisin B1, a poisonous compound that can contaminate corn and harm human and animal health. Remarkably, the fungus has evolved special protective mechanisms to survive its own poison. This study discovered that five genes in the fungus work together to shield it from fumonisin’s toxic effects by either breaking down the toxin or boosting the production of protective molecules called ceramides in cell membranes.

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Modeling Temperature Requirements for Growth and Toxin Production of Alternaria spp. Associated with Tomato

Researchers studied how temperature affects three types of Alternaria fungi that infect tomatoes and produce harmful toxins. They found that warm temperatures between 25-30°C are best for fungal growth and toxin production, though different species prefer slightly different temperatures. The study created mathematical formulas to predict when these fungi will contaminate tomatoes, which could help farmers prevent losses and protect food safety.

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