Anti-Therapeutic Action: Minimal toxicity to normal cells

Honeybee associated Aspergillus niger AW17 as a source of selective anticancer compounds with cytotoxicity evaluation in human cancer cell lines

Scientists discovered that a fungus found in honeybees can produce compounds that effectively kill cancer cells while leaving healthy cells largely unharmed. The fungus (Aspergillus niger AW17) contains unique bioactive compounds including high levels of oleic acid and a rare compound called pachymic acid. When tested against four types of human cancer cells, the fungal extract was particularly effective against liver and colorectal cancer. This finding suggests that exploring specialized environments like beehives could lead to new cancer treatments with fewer side effects.

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From Mushrooms to Molecules: Exploring Depsidones in Ganoderma lucidum for Antioxidant and Anticancer Applications

This research examined reishi mushroom (Ganoderma lucidum), a traditional medicinal fungus, to find rare compounds called depsidones with potential cancer-fighting properties. Scientists extracted these compounds using different solvents and tested them against four types of cancer cells (liver, colon, breast, and lung cancer), finding that they successfully killed cancer cells while being safe to normal cells. Using advanced chemical analysis and computer modeling, they identified nine new depsidone compounds in reishi and showed how these compounds could bind to cancer-related proteins to stop tumor growth.

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