Anti-Therapeutic Action: low systemic concentrations after oral administration

In Vitro Activity of Nitroxoline (5-Nitro-8-Hydroxyquinoline) Against Aspergillus Species

Researchers tested an old antibiotic called nitroxoline against Aspergillus fungi that cause serious infections in immunocompromised patients. The drug works by removing zinc that the fungus needs to survive. The study found that nitroxoline was very effective against all tested fungal strains, including those resistant to modern antifungal drugs, suggesting it could potentially be repurposed as a new treatment option.

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