Anti-Therapeutic Action: itraconazole

Challenges in Identifying Uncommon Clinical Isolates of Candida Species Using Conventional Phenotypic Methods: A Clinical Concern

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This study examined different methods for identifying Candida fungi in patient samples from a hospital in rural India. Researchers found that a dangerous fungus called Candida auris was being misidentified by traditional laboratory methods, while a newer automated system identified it correctly. The study also showed that many Candida infections are becoming resistant to common antifungal drugs, highlighting the need for better identification methods and careful drug selection.

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First human case of Eidernor doerrieniae colonization in a peritoneal dialysis catheter: A warning from silent contamination

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A 52-year-old dialysis patient noticed brownish particles inside his peritoneal dialysis catheter. Doctors identified a rare fungus called Eidernor doerrieniae using DNA sequencing, which had never been found in humans before. The catheter was removed and the patient received antifungal medications that successfully eliminated the infection without causing serious complications.

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The association of Yarrowia lipolytica with onychomycosis

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A 20-year-old woman had a persistent toenail infection that did not respond to multiple antifungal treatments. Researchers identified the cause as Yarrowia lipolytica, an unusual yeast that had never been found causing nail infections before. The yeast was resistant to several common antifungal medications, explaining why previous treatments failed. This case shows the importance of identifying the exact fungus causing an infection to develop effective treatment strategies.

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Geographical distribution of Cryptococcus neoformans in Iran, pathogenic factors, and antifungal susceptibility profile

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Researchers tested pigeon droppings from across Iran to find a dangerous fungus called Cryptococcus neoformans that can cause serious lung infections. They found this fungus in about 8.6% of samples, with more present in some provinces than others. The fungus showed concerning resistance to some common antifungal medications but remained sensitive to others like voriconazole, which could help guide treatment decisions.

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Masquerading Yeast: A Case Report of Lomentospora prolificans Fungemia With a Diagnostic Twist

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This case describes a patient with blood cancer who developed a rare and deadly mold infection called Lomentospora prolificans while receiving cancer treatment. The infection was difficult to diagnose initially because the fungal structures looked similar to yeast under the microscope, and a molecular test gave a false positive result for a different fungus. Unfortunately, the infection was resistant to all available antifungal medications and the patient died.

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First human case of Eidernor doerrieniae colonization in a peritoneal dialysis catheter: A warning from silent contamination

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A 52-year-old man on peritoneal dialysis noticed brownish particles in his dialysis catheter. Doctors identified the particles as a rare fungus called Eidernor doerrieniae, which had never been found in humans before. Although the patient had no symptoms, doctors immediately removed the catheter and treated him with antifungal medications, which successfully cured the infection. This case shows why patients and doctors should take visible particles in dialysis catheters seriously, even when there are no obvious signs of infection.

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Simplicillium sinense sp. nov., a novel potential pathogen of tinea faciei

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Researchers identified a new fungal species called Simplicillium sinense that caused a facial skin infection (tinea faciei) in a 46-year-old man with diabetes. The fungus was resistant to most common antifungal medications but responded well to terbinafine treatment. This is the first reported case of a Simplicillium infection causing facial ringworm, expanding our understanding of rare fungal pathogens.

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