Anti-Therapeutic Action: increased stress sensitivity

Context-Dependent Fitness Trade-Offs in Penicillium expansum Isolates Resistant to Multiple Postharvest Fungicides

This research examines how apples and pears get a fungal disease called blue mold and how the fungus develops resistance to commonly used fungicides. Scientists tested fungus samples that resist different fungicides to see if this resistance makes them weaker. They found that resistant fungus strains do struggle more under stressful laboratory conditions, but remain dangerous during long-term cold storage of fruit, especially when fungicides are present.

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SsMet1 is a critical gene in methionine biosynthesis in Sclerotinia sclerotiorum

Sclerotinia sclerotiorum is a destructive plant pathogen causing white mold and other crop diseases. This study identified and deleted the SsMet1 gene, which is essential for methionine production in this fungus. Fungi lacking this gene could not grow properly, form survival structures called sclerotia, or infect plants. These findings suggest that blocking methionine biosynthesis could be a new way to develop fungicides against this important crop pathogen.

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