Anti-Therapeutic Action: Inactivation through N-methylation

Genome-Mining Based Discovery of Pyrrolomycin K and L from the Termite-Associated Micromonospora sp. RB23

Researchers discovered two new antimicrobial compounds called pyrrolomycins from a bacterium found in termite guts using genome analysis and advanced chemistry techniques. These compounds are modified versions of known antimicrobial molecules, featuring halogenated structures. Interestingly, the bacteria appears to protect itself from its own toxic compounds through chemical modifications, a strategy that researchers believe could inform the design of new antibiotics to combat drug-resistant bacteria.

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