Anti-Therapeutic Action: IL-4 suppression of Th17 cells

Abundant Yet Aberrant T Helper Cell Responses to Candida albicans Underlie Mucosal Candidiasis in Humans and Mice

Researchers studied how the immune system fights Candida albicans fungal infections. They found that a specific type of immune cell called Th17 cells is absolutely essential for controlling these infections, while other immune cells called Th2 cells actually make infections worse by blocking the protective Th17 cells. Patients with certain genetic mutations that affect how their immune system works have too many Th2 cells and not enough Th17 cells, making them vulnerable to chronic fungal infections. The study suggests that blocking a molecule called IL-4 could help restore the balance and improve patient outcomes.

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