Anti-Therapeutic Action: hypersensitivity reactions

Basidiobolomycosis caused by a rare species – Basidiobolus meristosporus

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A five-year-old girl developed large swollen lumps on her buttock and thigh that were initially thought to be tuberculosis or cancer. Doctors took a tissue sample and found it was caused by a rare fungus called Basidiobolus meristosporus. Using advanced DNA sequencing techniques, they identified the exact fungus species and treated her successfully with an antifungal medication called itraconazole, leading to complete healing within six weeks.

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Cunninghamella echinulata DSM1905 biofilm-based L-asparaginase production in pneumatically-driven bioreactors

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Scientists tested different types of bioreactors to grow a fungus called Cunninghamella echinulata that produces L-asparaginase, an enzyme used to treat leukemia and lymphoma. They found that a special hybrid bioreactor with a mesh scaffold allowed the fungus to form a biofilm, which produced significantly more of the therapeutic enzyme than other reactor types. This discovery could improve the production of cancer-fighting medications.

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Submerged Fermentation of Rhizopus sp. for l-asparaginase Production in Lymphoma Therapy

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Researchers developed a new way to produce an anti-cancer enzyme called L-asparaginase using a fungus called Rhizopus, which could offer a safer alternative to current bacterial sources. They designed and tested a special bioreactor system that allows the fungus to grow as a biofilm, significantly increasing enzyme production. The system achieved enzyme activity levels much higher than previous laboratory methods, suggesting it could be scaled up for industrial pharmaceutical production.

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