Eumycetoma is a serious fungal infection that causes large skin lesions and is very difficult to treat, even with long-term medication and surgery. Researchers used computer analysis to identify proteins called kinases that are essential for the fungus to survive. They found that targeting kinases involved in building the fungal cell wall could potentially lead to new treatments. By testing existing drugs, they discovered eight compounds that could inhibit fungal growth, offering hope for better treatment options.