hepatotoxicity – Page 2

A Review of Research Progress on the Microbial or Enzymatic Degradation and Mechanism of Aflatoxin B1

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Aflatoxin B1 is a dangerous toxin found in contaminated cereals and food products that can cause serious diseases including liver cancer. Scientists have discovered that certain bacteria and fungi can naturally break down this toxin into less harmful substances through their enzymes. This review summarizes different microorganisms and enzymes that can degrade aflatoxin B1, explaining how they work and what safe products they create, offering hope for safer food storage and treatment.

Clinical Mycology Today: Emerging Challenges and Opportunities

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Fungal infections are becoming more common because of new medical treatments that suppress immune function, and some fungi are developing resistance to standard medications. However, exciting new antifungal drugs are in development that work in different ways and may be easier to use. The article discusses how doctors need better ways to identify patients at risk, design better clinical trials, and train more specialists to handle these increasingly complex fungal infections.

Negative Effects of Occurrence of Mycotoxins in Animal Feed and Biological Methods of Their Detoxification: A Review

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Molds that grow on grains and feed produce toxic substances called mycotoxins that can seriously harm farm animals, causing liver and kidney damage, reproductive problems, and reduced productivity. While proper storage and farming practices help prevent contamination, some mycotoxins still get through. Recent research shows that beneficial bacteria like those in yogurt and certain yeasts can effectively remove these toxins from animal feed, making it safer for livestock while protecting the environment from harmful chemicals.

Discovery of novel targets for important human and plant fungal pathogens via an automated computational pipeline HitList

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Researchers created a computer program called HitList that searches fungal DNA to find new targets for antifungal medications. The program identified 16 promising protein targets that could be attacked by new antifungal drugs, including 8 completely new targets never before considered. This discovery could help develop new antifungal treatments to fight drug-resistant fungal infections in both humans and crops.

Methods for Overcoming Chemoresistance in Head and Neck Squamous Cell Carcinoma: Keeping the Focus on Cancer Stem Cells, a Systematic Review

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Head and neck cancer is often resistant to chemotherapy because of cancer stem cells that survive treatment and cause recurrence. This review examined 31 studies on methods to overcome this resistance, finding that natural products like mushrooms (Ganoderma lucidum), plants (sulforaphane from broccoli, curcumin from turmeric), and synthetic compounds can enhance chemotherapy effectiveness when combined with traditional drugs. These approaches work by targeting the specific pathways that allow cancer stem cells to survive, potentially improving treatment outcomes while reducing required drug doses and side effects.

How Should the Worldwide Knowledge of Traditional Cancer Healing Be Integrated with Herbs and Mushrooms into Modern Molecular Pharmacology?

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This comprehensive review explores how traditional healing practices from around the world use plants and mushrooms to treat cancer. The authors examine thousands of plant species and their active compounds that show promise in fighting various types of cancer through multiple mechanisms like stopping cancer cell growth and triggering cell death. The review emphasizes that proper scientific validation, standardization, and safety testing can help integrate these traditional remedies into modern cancer treatment alongside conventional chemotherapy.

Recent innovations and challenges in the treatment of fungal infections

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Fungal infections are becoming more common and dangerous, especially for people with weakened immune systems, and many fungi are developing resistance to current medications. Doctors and researchers are developing new treatment strategies, including combining multiple drugs together and using advanced technologies to deliver medicines more effectively to infected areas. Natural compounds from plants and new biotechnology tools like genetic engineering and nanoparticles show promising results for fighting drug-resistant fungal infections.

Efficacy of Rezafungin on Candida albicans Endophthalmitis in a Rabbit Model

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Researchers tested a new antifungal drug called rezafungin against a serious eye infection caused by Candida fungus in rabbits. Rezafungin performed much better than two other commonly used antifungal drugs, completely eliminating the fungus from the eye while preventing infection-related damage. The drug’s ability to be given weekly instead of daily makes it more practical for treating patients with severe fungal eye infections.

Removal of Aflatoxin B1 by Edible Mushroom-Forming Fungi and Its Mechanism

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This research discovered that edible mushroom varieties, particularly Bjerkandera adusta, can remove harmful aflatoxin B1 poison from food and animal feed. The mushroom fungi work by binding the toxin to their cell structures, acting like a sponge that soaks up the dangerous chemical. This natural method is safer and more practical than chemical or heat-based approaches because it doesn’t damage the nutritional value of food while making it safer to eat.

Isavuconazonium Utilization in Pediatric Patients at a Free-Standing Children’s Hospital

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Researchers at Children’s Hospital Los Angeles studied how well a newer antifungal medication called isavuconazonium works in children with cancer and blood disorders who are at high risk for serious fungal infections. The medication was recently approved for use in children ages 1 and older. The study found that the medication was generally safe and effective, though doctors need to monitor liver function and drug levels to ensure proper dosing and catch any side effects early.

Anti-Therapeutic Action: hepatotoxicity