hepatotoxicity – mycolab.ai

Nutritional strategies in supporting immune checkpoint inhibitor, PI3K inhibitor, and tyrosine kinase inhibitor cancer therapies

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This review examines how nutrition and food-based interventions can improve cancer treatment outcomes for patients receiving targeted cancer therapies. A Mediterranean-style diet with plenty of fiber (30-50g daily) appears beneficial for patients on immune checkpoint inhibitor therapies by promoting healthy gut bacteria that support immune function. The review also discusses promising research on fermented foods, specific bacterial supplements, mushroom extracts, and fasting approaches as complementary strategies to enhance cancer treatment effectiveness while reducing side effects.

Ganoderma lingzhi (Reishi Mushroom)-Induced Acute Liver Injury in the Setting of Alcohol Use: A Case Report and Review of the Literature

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A 47-year-old man developed severe liver inflammation after consuming Reishi mushroom powder while drinking large amounts of vodka over three days. Although Reishi mushrooms are commonly promoted as healthy supplements, in this case the combination with alcohol caused his liver enzymes to spike dangerously high. The patient recovered after hospital treatment, but the case highlights that even natural supplements can be harmful, especially when combined with alcohol. This raises concerns that more research is needed on how mushroom supplements interact with other substances people consume.

Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

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This review examines how natural products from plants, fungi, and marine organisms can help treat liver cancer more safely and effectively than current drugs. These natural compounds work through multiple pathways such as triggering cancer cell death, stopping cell growth, and boosting the immune system. The research found that seven categories of natural products show promise, with sources ranging from ginseng and turmeric to mushrooms and seaweed, offering potential new treatment options that could reduce side effects and drug resistance.

Acute Kidney Failure and Myocarditis Triggered by Magic Mushroom Toxicity in a Patient With Prior Cocaine Exposure

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A middle-aged man who used magic mushrooms along with alcohol and LSD developed severe kidney failure and heart inflammation. He had previously used cocaine, which made his condition worse by promoting blood clots throughout his body. Despite dialysis treatment, his kidneys stopped working, he developed heart problems and blood clots in major blood vessels, and he unfortunately passed away. This case highlights how dangerous it can be to mix magic mushrooms with other drugs, especially for people with a history of cocaine use.

Aflatoxin B1 (AFB1) biodegradation by a lignolytic phenoloxidase of Trametes hirsuta

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Scientists discovered that a mushroom called Trametes hirsuta produces a special enzyme that can break down aflatoxin B1, a dangerous toxin that contaminates foods like peanuts, corn, and nuts. This enzyme is unique because it works without needing additional chemicals as helpers, making it practical for real-world use. The enzyme successfully degraded 77.9% of the toxin under simple conditions, and researchers suggest it could be applied directly to contaminated food surfaces as a safe, natural way to reduce food poisoning risks.

A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment

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Fungi naturally produce complex chemical compounds called secondary metabolites that have powerful effects against diseases and pests. These include well-known medicines like penicillin and compounds that can fight cancer, reduce inflammation, and lower cholesterol. Scientists are now using advanced genetic and biotechnology techniques to increase production of these fungal compounds, making them more available and affordable for medical, agricultural, and environmental applications. This research shows how fungi could be important sources of new medicines and sustainable alternatives to synthetic chemicals.

Fungal Metabolomics: A Comprehensive Approach to Understanding Pathogenesis in Humans and Identifying Potential Therapeutics

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This review explains how scientists use metabolomics—a technique that identifies all chemical compounds in organisms—to understand how fungi cause disease and resist medicines. Fungi produce many different chemicals that help them attack our bodies and survive treatments, but these same chemicals could also be used to create new medicines. By studying these fungal chemicals, researchers can develop better antifungal drugs and understand how fungi manage to evade our immune system.

When Nature Meets Oncology: Unraveling Herb–Drug Interactions in Cancer Therapy

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Many cancer patients use herbal supplements and natural products alongside their cancer treatments without telling their doctors, which can be dangerous. Some natural products like St. John’s Wort and grapefruit juice significantly alter how the body processes cancer medications, potentially making treatments ineffective or toxic. The review provides guidance on which natural products are safe to use with cancer therapy and which should be avoided completely, emphasizing the importance of open communication between patients and healthcare providers.

A comprehensive review of mycotoxins, their toxicity, and innovative detoxification methods

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Mycotoxins are poisons produced by molds that commonly contaminate foods like grains, nuts, and spices, causing serious health problems in people and animals. This comprehensive review examines how these toxins affect our health, how to detect them in food, and various methods to remove or destroy them. Traditional approaches using biological agents and chemicals work well but are only partially effective, while newer innovative methods using nanoparticles and plant extracts show greater promise for more complete protection of our food supply.

Increased Dissemination of Aflatoxin- and Zearalenone-Producing Aspergillus spp. and Fusarium spp. during Wet Season via Houseflies on Dairy Farms in Aguascalientes, Mexico

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This study found that during rainy seasons on Mexican dairy farms, houseflies carry more mold spores that produce harmful toxins called aflatoxins and zearalenone. These toxins contaminate cattle feed and milk, posing health risks to both animals and humans. The research shows that controlling houseflies during wet seasons is crucial to reduce toxic mold contamination of dairy products and animal feed.

Anti-Therapeutic Action: hepatotoxicity