genotoxicity – mycolab.ai

Ambient ultraviolet radiation induces DNA damage in amphibian larvae under semi-natural conditions

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Scientists studied whether natural sunlight damages the DNA of tadpoles by raising striped marsh frog larvae in outdoor pools with either normal or reduced sun exposure. They found that natural sunlight does cause measurable DNA damage in tadpoles, and some individual tadpoles were more affected than others. This research suggests that as UV radiation changes due to climate change, some amphibian populations may face greater risks to their survival and development.

Fungal Metabolomics: A Comprehensive Approach to Understanding Pathogenesis in Humans and Identifying Potential Therapeutics

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This review explains how scientists use metabolomics—a technique that identifies all chemical compounds in organisms—to understand how fungi cause disease and resist medicines. Fungi produce many different chemicals that help them attack our bodies and survive treatments, but these same chemicals could also be used to create new medicines. By studying these fungal chemicals, researchers can develop better antifungal drugs and understand how fungi manage to evade our immune system.

The Global Secondary Metabolite Regulator AcLaeA Modulates Aspergillus carbonarius Virulence, Ochratoxin Biosynthesis, and the Mode of Action of Biopesticides and Essential Oils

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Grapes can be infected with a fungus called Aspergillus carbonarius that produces a dangerous toxin called ochratoxin A. Scientists studied a regulatory gene called AcLaeA that controls toxin production in this fungus. By deleting this gene, the fungus became less virulent and produced much less toxin. Natural products like cinnamon and thyme oils, along with commercial biocontrol products, were found to reduce toxin production by suppressing this regulatory gene, offering promising natural alternatives to chemical fungicides.

Molecular Docking, Synthesis, and Tyrosinase Inhibition Activity of Acetophenone Amide: Potential Inhibitor of Melanogenesis

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Researchers developed new chemical compounds that can inhibit tyrosinase, an enzyme responsible for producing melanin (the pigment that colors skin). One compound, called 5c, proved exceptionally effective at blocking this enzyme—significantly more potent than existing skin-lightening agents. These acetophenone-based compounds could lead to improved cosmetic treatments for unwanted pigmentation like age spots and melasma, with better safety profiles than current options.

Molecular identification and mycotoxins analysis of some fungal isolates from postharvest decayed apple in Qena, Egypt

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Apples stored after harvest can be infected by blue mold fungi that produce toxic substances called mycotoxins. Researchers in Egypt identified five fungal strains from rotted apples and measured the amounts of two dangerous toxins they produce. The findings show that these fungi can cause significant food safety risks and economic losses, highlighting the need for better storage and handling practices.

Pharmaceutical Pollution in Aquatic Environments: A Concise Review of Environmental Impacts and Bioremediation Systems

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Medications we take for health are ending up in our water supplies in significant amounts because standard water treatment plants cannot remove them effectively. These pharmaceutical residues are harming wildlife and aquatic ecosystems, causing problems like population declines in birds, developmental issues in fish, and the spread of antibiotic resistance. Scientists are developing new bioremediation technologies, particularly using fungi and mycoremediation, to better remove these drugs from wastewater before they reach our water bodies.

Identification of (Z)-2-benzylidene-dihydroimidazothiazolone derivatives as tyrosinase inhibitors: Anti-melanogenic effects and in silico studies

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Scientists developed new chemical compounds that can block tyrosinase, an enzyme that produces skin pigment (melanin). These new compounds, called DHIT derivatives, work much better than existing skin lightening agents like kojic acid and appear to be safer. The best compound tested was 100 times more effective at stopping melanin production than kojic acid in laboratory tests and showed no toxicity to cells.

Anti-Therapeutic Action: genotoxicity

Ambient ultraviolet radiation induces DNA damage in amphibian larvae under semi-natural conditions

Fungal Metabolomics: A Comprehensive Approach to Understanding Pathogenesis in Humans and Identifying Potential Therapeutics

The Global Secondary Metabolite Regulator AcLaeA Modulates Aspergillus carbonarius Virulence, Ochratoxin Biosynthesis, and the Mode of Action of Biopesticides and Essential Oils

Molecular Docking, Synthesis, and Tyrosinase Inhibition Activity of Acetophenone Amide: Potential Inhibitor of Melanogenesis

Molecular identification and mycotoxins analysis of some fungal isolates from postharvest decayed apple in Qena, Egypt

Pharmaceutical Pollution in Aquatic Environments: A Concise Review of Environmental Impacts and Bioremediation Systems

Identification of (Z)-2-benzylidene-dihydroimidazothiazolone derivatives as tyrosinase inhibitors: Anti-melanogenic effects and in silico studies