Anti-Therapeutic Action: Fluconazole limited effectiveness

Emergence of resistant dermatophytosis caused by Trichophyton indotineae: First case series in Thailand

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Researchers in Thailand have identified five patients with a difficult-to-treat fungal skin infection caused by Trichophyton indotineae, a type of dermatophyte that resists the commonly used antifungal drug terbinafine. This is the first time this resistant fungus has been detected in Thailand. The team developed a simple, inexpensive test using urease to help identify these resistant infections more easily. Patients responded well to the antifungal drug itraconazole after other treatments failed.

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Sarocladium implicatum: an unusual agent of opportunistic infection in a COVID-19 patient

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A 64-year-old man hospitalized with COVID-19 developed a serious fungal infection from Sarocladium implicatum, an unusual fungus rarely found in humans. The infection appeared in his bloodstream and lungs while his immune system was severely weakened by the virus and medications. Doctors identified the fungus using genetic testing and successfully treated him with voriconazole antifungal medication. This case highlights how COVID-19 patients in intensive care are vulnerable to rare opportunistic infections that require specialized laboratory testing to identify and treat.

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