Anti-Therapeutic Action: FgPhm1 deletion reduces virulence and DON production but causes sensitivity to oxidative stress

The phenol-2-monooxygenase FgPhm1 regulates DON synthesis, pathogenicity and environmental stress response in Fusarium graminearum

Researchers studied a fungal protein called FgPhm1 in a wheat-infecting fungus that produces harmful toxins called DON. By deleting this gene, they found that the fungus became unable to infect plants and produce toxins, making it less dangerous. The protein also helps the fungus handle stress conditions, and removing it makes the fungus sensitive to oxidative stress while paradoxically tolerant to phenol.

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