Researchers in Thailand found that certain fungal infections caused by Aspergillus fumigatus are becoming resistant to common antifungal medications like voriconazole. They identified a specific genetic mutation called TR34/L98H in one patient sample that makes the fungus resistant to azole drugs used to treat these serious infections. By analyzing the genetic makeup of these resistant fungi, scientists discovered additional changes beyond the known resistance gene, suggesting these organisms may adapt in multiple ways to survive treatment. This is the first time this particular resistance mutation has been detected in a clinical patient sample in Thailand, indicating that antifungal resistance in Aspergillus is spreading and requires closer monitoring and testing.