This research shows that shiitake mushrooms (Lentinula edodes) can help clean up antifungal medications that contaminate water and soil. When the mushroom mycelium was exposed to two common antifungal drugs used in creams and treatments, it absorbed and broke down these compounds. The mushrooms degraded about one-third of the drugs by targeting their chemical structure, particularly the imidazole ring. This suggests mushrooms could be used as a natural, cost-effective solution for removing pharmaceutical pollution from the environment.