Anti-Therapeutic Action: dry mouth

Psilocybin for treatment resistant depression in patients taking a concomitant SSRI medication

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Researchers tested whether people with severe depression could take psilocybin (a compound from certain mushrooms) while staying on their antidepressant medications. In this study of 19 people, those who received psilocybin with psychological support while continuing their SSRI showed significant improvement in depression symptoms over three weeks, with response rates of 42%. Side effects were mostly mild and temporary, suggesting this approach may be safe and effective without requiring patients to stop their current antidepressants.

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New and emerging pharmacologic treatments for MDD

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Major depressive disorder affects millions worldwide and current antidepressants often don’t work well or take weeks to be effective. Researchers have developed exciting new treatments that work through different brain mechanisms and show promise for rapid symptom relief. These include nasal spray ketamine (approved 2019), oral medications like zuranolone (approved 2023), and investigational treatments including psilocybin, which show benefits especially for treatment-resistant cases. While many show great promise, more research is needed on long-term safety and how to make them widely available.

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Methods for Overcoming Chemoresistance in Head and Neck Squamous Cell Carcinoma: Keeping the Focus on Cancer Stem Cells, a Systematic Review

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Head and neck cancer is often resistant to chemotherapy because of cancer stem cells that survive treatment and cause recurrence. This review examined 31 studies on methods to overcome this resistance, finding that natural products like mushrooms (Ganoderma lucidum), plants (sulforaphane from broccoli, curcumin from turmeric), and synthetic compounds can enhance chemotherapy effectiveness when combined with traditional drugs. These approaches work by targeting the specific pathways that allow cancer stem cells to survive, potentially improving treatment outcomes while reducing required drug doses and side effects.

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