Anti-Therapeutic Action: drug resistance

Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

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This review examines how natural products from plants, fungi, and marine organisms can help treat liver cancer more safely and effectively than current drugs. These natural compounds work through multiple pathways such as triggering cancer cell death, stopping cell growth, and boosting the immune system. The research found that seven categories of natural products show promise, with sources ranging from ginseng and turmeric to mushrooms and seaweed, offering potential new treatment options that could reduce side effects and drug resistance.

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Biological Activities of Secondary Metabolites from the Edible-Medicinal Macrofungi

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This comprehensive review examines over 270 bioactive compounds from edible and medicinal mushrooms, showing they have remarkable potential to treat various diseases. These mushroom-derived substances demonstrate effectiveness against cancer, diabetes, inflammation, and infections while having fewer side effects than conventional drugs. Families like reishi and shiitake mushrooms are particularly rich sources of these healing compounds. The research suggests mushrooms are valuable natural resources for developing new therapeutic treatments.

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Analysis of Susceptibility and Drug Resistance of Antifungal Agents in Aspergillosis and Mucormycosis Patients: A Systematic Review

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This comprehensive study analyzed how well five major antifungal drugs work against common disease-causing fungi like Aspergillus and Mucorales. Researchers reviewed 96 studies examining over 16,000 fungal samples to understand resistance patterns. The findings show that different fungi respond better to different drugs—for example, Aspergillus flavus responds well to voriconazole, while amphotericin B works best against other Aspergillus species. This information helps doctors choose the most effective treatments for fungal infections in vulnerable patients.

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Musculoskeletal Manifestations of Disseminated Fungal Infections

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Fungal infections can spread to bones and joints, causing serious complications especially in people with weakened immune systems. These infections are tricky to diagnose because their symptoms are similar to bacterial infections or other diseases. Treatment typically involves antifungal medications and sometimes surgery to remove infected tissue. Early detection and aggressive treatment are crucial for better patient outcomes.

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Peritoneal dialysis-related peritonitis caused by Fusarium: a case report and literature review

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A 61-year-old farmer with kidney disease on peritoneal dialysis developed a rare fungal infection caused by Fusarium, a fungus found in soil and water. After initial antibiotics failed, doctors identified the fungus and switched to an antifungal medication called voriconazole. By carefully monitoring drug levels in the patient’s blood and adjusting doses, pharmacists helped achieve a successful recovery with complete resolution of symptoms.

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Endogenous Endophthalmitis: An underestimated serious complication in patients with disseminated fusariosis

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An 18-year-old boy with acute leukemia developed a serious fungal infection caused by Fusarium mold that spread throughout his body, including to both eyes. Despite receiving intensive antifungal medications injected directly into his eyes along with systemic treatment, he lost his vision. However, through aggressive combined therapy, doctors were able to save both eyes and continue his cancer treatment successfully.

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John Perfect Shares Insights on Infectious Diseases, Antifungal Therapy, and Drug Resistance

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Dr. John Perfect shares decades of experience treating fungal infections and developing antifungal medications. He discusses how treatments have evolved from highly toxic drugs to more effective options, but notes that fungal infections remain challenging, especially when patients develop resistance or have serious underlying diseases. He emphasizes the importance of combining drugs with immune therapies and shorter, more potent treatments rather than lengthy medication courses. Despite challenges, Dr. Perfect is optimistic about the future of medicine and encourages young scientists to pursue careers in this field.

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