Anti-Therapeutic Action: drug efflux-mediated resistance

Aspergillus fumigatus ctf1 – a novel zinc finger transcription factor involved in azole resistance

Researchers discovered that a gene called ctf1 in a harmful fungus called Aspergillus fumigatus helps control how resistant the fungus is to antifungal medications like voriconazole. When this gene is removed, the fungus becomes more resistant to these drugs because it pumps them out more efficiently. Understanding this mechanism could help doctors develop better treatments for serious fungal infections in vulnerable patients.

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