Anti-Therapeutic Action: DNA damage

Adaptive responses of Gordonia alkanivorans IEGM 1277 to the action of meloxicam and its efficient biodegradation

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This research demonstrates that a bacterium called Gordonia alkanivorans can break down meloxicam, a commonly used anti-inflammatory drug that pollutes our environment. The bacteria successfully converted the harmful drug into less toxic byproducts over two weeks. The study reveals how the bacteria adapted to handle the drug stress and identified the specific genes and enzymes responsible for the degradation process. These findings could lead to new biological methods for cleaning pharmaceutical pollutants from wastewater.

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Harnessing pycnidia-forming fungi for eco-friendly nanoparticle production, applications, and limitations

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Certain types of fungi can produce tiny metal particles called nanoparticles that have useful properties. These fungi-made nanoparticles can kill bacteria, fight cancer cells, clean pollutants from water and soil, and be used in medicines and agriculture. Unlike traditional chemical methods for making nanoparticles, using fungi is cleaner and safer for the environment, though scientists still need to understand more about how they work and ensure they are safe to use widely.

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Inonotus obliquus aqueous extract prevents histopathological alterations in liver induced by environmental toxicant Microcystin

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This research shows that Chaga mushroom extract can protect the liver from damage caused by microcystin, a toxic chemical produced by cyanobacteria in water. When mice were exposed to microcystin, their livers became damaged, but treating them with Chaga mushroom extract restored normal liver function and prevented cell death. The study suggests Chaga mushroom could be used as a natural supplement to prevent liver toxicity from environmental pollutants.

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Harnessing pycnidia-forming fungi for eco-friendly nanoparticle production, applications, and limitations

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Certain fungi called pycnidial fungi can create tiny particles called nanoparticles that are useful in medicine, agriculture, and environmental cleanup. These fungi naturally produce chemicals and enzymes that reduce metal ions into nanoparticles, which have antimicrobial and cancer-fighting properties. While this biological approach is more environmentally friendly than chemical methods, scientists still need to solve challenges like making it work at large scales and ensuring the nanoparticles are safe and stable.

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Removal of Aflatoxin B1 by Edible Mushroom-Forming Fungi and Its Mechanism

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This research discovered that edible mushroom varieties, particularly Bjerkandera adusta, can remove harmful aflatoxin B1 poison from food and animal feed. The mushroom fungi work by binding the toxin to their cell structures, acting like a sponge that soaks up the dangerous chemical. This natural method is safer and more practical than chemical or heat-based approaches because it doesn’t damage the nutritional value of food while making it safer to eat.

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Transcriptional programs mediating neuronal toxicity and altered glial–neuronal signaling in a Drosophila knock-in tauopathy model

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Researchers created a fruit fly model of frontotemporal dementia by editing the tau gene to match a human disease mutation. Using advanced genetic sequencing technology, they analyzed how this mutation affects brain cells, discovering that it disrupts communication between nerve cells and support cells called glia. The study reveals multiple pathways that could be targeted with future treatments to combat this devastating brain disease.

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