Anti-Therapeutic Action: biofilm-mediated antifungal resistance

Candida krusei Empyema: A Lung Transplant Case and Systematic Review of the Literature

Candida krusei is a dangerous fungus that can cause fluid buildup around the lungs (empyema), particularly in transplant patients. Unlike common fungal infections that respond to fluconazole, this species is naturally resistant to this drug, making it harder to treat. The fungus forms protective biofilms that shield it from treatment, requiring combination antifungal medications and sometimes surgery to drain the fluid and remove infected tissue for successful recovery.

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Clinical profiling, antifungal drug susceptibility, and biofilm formation ability in pulmonary mucormycosis

This study examined 26 patients with a serious lung fungal infection called mucormycosis in a Beijing hospital. Most patients were older with health problems like diabetes and high blood pressure, and sadly about 4 in 10 died. Interestingly, most patients had other infections (viral or fungal) before developing mucormycosis. The researchers tested which antifungal drugs worked best against the fungus, finding that amphotericin B was most effective, though it can damage kidneys. They also discovered that most of the fungal strains could form protective biofilm structures, making treatment more difficult.

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