Anti-Therapeutic Action: amphotericin B

A case of rare fungal keratitis caused by Pseudoshiraia conidialis

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A 61-year-old woman scratched her eye with a bamboo branch and developed a serious fungal eye infection caused by a rare fungus called Pseudoshiraia conidialis. This is the first reported case of this particular fungus infecting human eyes. Although initial treatment with antifungal medications showed promise, the infection proved difficult to cure due to the fungus being resistant to multiple antifungal drugs. The case highlights the importance of early diagnosis and treatment of fungal eye infections.

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A Zn2-Cys6 transcription factor, TgZct4, reprograms antioxidant activity in the fungus Trichoderma guizhouense to defend against oxidative stress

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Trichoderma guizhouense is a fungus used to protect plants from harmful pathogens. Researchers discovered that a special protein called TgZct4 acts like a master switch that activates the fungus’s defense system against harmful reactive oxygen molecules. When the fungus encounters stress, TgZct4 turns on genes that produce protective enzymes called catalases and superoxide dismutases, helping the fungus survive. This discovery could help scientists create even more effective biological pest control products.

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Performance Evaluation of Five Real-Time PCR Assays for the Detection of Candida auris DNA

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Candida auris is a dangerous fungal infection that spreads in hospitals and resists common antifungal medications. Researchers compared five different rapid tests (PCR assays) to see which ones best detect this pathogen. The study found that different tests vary widely in their ability to detect the fungus, with some being much more sensitive than others. The findings highlight the need for standardized testing methods worldwide to ensure hospitals can reliably identify and control C. auris infections.

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Pathogenic characterization of Phialophora submersa, a new black yeast isolated from freshwater sediments in Spain

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Scientists discovered a new black yeast fungus called Phialophora submersa in Spanish river sediments and tested whether it could infect humans. Using laboratory macrophage (immune cell) models, they found that this environmental fungus exhibits pathogenic potential similar to known disease-causing Phialophora species, though at intermediate levels. The fungus showed resistance to some antifungal drugs and displayed strain-dependent ability to survive various stress conditions. This research suggests that environmental fungal species may pose unexpected health risks despite not being able to grow at normal human body temperature.

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