Anti-Therapeutic Action: airway remodeling

Lentinan Alleviated PM2.5 Exposure-Induced Epithelial–Mesenchymal Transition in Pulmonary Epithelial Cells by Inhibiting the GARP/TGF-β/Smad Pathway

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Air pollution particles (PM2.5) can cause serious lung damage by triggering a process called epithelial-mesenchymal transition, where lung cells lose their protective qualities. This study found that a natural compound called lentinan, derived from shiitake mushrooms, can help prevent this harmful process by blocking a protein called GARP. The research suggests that lentinan could be a promising natural treatment for lung diseases caused by air pollution.

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Microfungus Podosphaera fusca and the Fungus-like Organism Peronospora ficariae as Potential Inhalant Allergens in a Mouse Model of Asthma

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Scientists studied two fungi that infect plants to see if they could cause asthma-like reactions in mice. They found that these fungi triggered inflammatory responses and produced antibodies similar to other known allergens. While not as potent as ovalbumin (a common test allergen), these plant-infecting fungi showed potential as respiratory allergens that may affect people exposed to them.

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Microfungus Podosphaera fusca and the Fungus-like Organism Peronospora ficariae as Potential Inhalant Allergens in a Mouse Model of Asthma

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This study investigated whether two plant parasites that cause powdery and downy mildew could trigger asthma-like reactions in mice. Researchers found that extracts from these fungi induced immune responses similar to those caused by known allergens like ovalbumin, though somewhat weaker. The results suggest these organisms should be recognized as potential sources of respiratory allergies in humans. This finding may help explain some cases of allergies where the specific cause has been difficult to identify.

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Microfungus Podosphaera fusca and the Fungus-like Organism Peronospora ficariae as Potential Inhalant Allergens in a Mouse Model of Asthma

mycolabadmin

Researchers studied two types of plant fungi that infect common vegetables and plants to determine if they could cause asthma in mice. They found that both organisms triggered immune responses similar to those caused by known allergens, producing inflammation and asthma-like symptoms. Although their effects were weaker than the reference allergen ovalbumin, both fungi showed significant potential as respiratory allergens. This research suggests these plant parasites should be recognized as possible triggers for asthma and allergic reactions in people.

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