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Whole genome sequencing and annotations of Trametes sanguinea ZHSJ

Summary

Scientists have completely mapped the genetic code of Trametes sanguinea, a medicinal mushroom used in traditional Chinese medicine. They identified over 10,000 genes and analyzed how this mushroom produces compounds that fight tumors, boost immunity, protect the heart, and fight viruses. This genetic map will help researchers understand how to produce these beneficial compounds and develop new medicines from this mushroom.

Background

Trametes sanguinea is an edible and medicinal fungus from the polyporaceae family widely cultivated in Yunnan province, China. Its fruiting body contains polysaccharides with potential therapeutic benefits including antitumor, immunomodulatory, cardioprotective, antimicrobial, and antiviral activities. Complete genomic information of T. sanguinea strains could facilitate research into biosynthetic pathways of medicinally important compounds.

Objective

To perform whole genome sequencing and transcriptome analysis of Trametes sanguinea ZHSJ strain isolated from chestnut tree wood with comprehensive functional annotations. The study aimed to provide genomic resources and gene annotations to support further research into the medicinal properties and industrial applications of this fungus.

Results

The T. sanguinea ZHSJ genome is 41.3243 Mb in length with 135 contigs and N50 contig length of 2.8138 Mb. A total of 10,886 genes were annotated, with transcriptome assembly revealing 11,861 genes and de novo prediction identifying 12,268 coding genes. SSR analysis identified 1,242 simple sequence repeats with trinucleotide repeats being the most abundant. BUSCO analysis confirmed 94.3% complete assembly.

Conclusion

The high-quality whole genome and transcriptome assembly and annotation of Trametes sanguinea ZHSJ provides comprehensive genomic resources for future research. These data support investigations into specific genes responsible for medicinally important compound production and enable industrial genetic bioengineering applications. The genomic information establishes a foundation for understanding T. sanguinea’s biosynthetic pathways and therapeutic potential.
  • Published in:Scientific Data,
  • Study Type:Genomic Sequencing Study,
  • Source: 10.1038/s41597-025-05798-9, PMID: 40841404
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