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Whole genome sequencing and annotations of Trametes sanguinea ZHSJ

Summary

Scientists sequenced the complete genome of Trametes sanguinea, a medicinal mushroom used in traditional Chinese medicine, grown in China. The mushroom’s tissue contains beneficial compounds that may help fight tumors, protect the heart, boost immunity, and heal diabetic wounds. By mapping out all 10,886 genes in this fungus, researchers now have detailed blueprints to understand how it produces these healing compounds and potentially grow them industrially for medical use.

Background

Trametes sanguinea is an edible and medicinal fungus from the Polyporaceae family widely cultivated in China. Its fruiting body contains polysaccharides with various medicinal benefits including antitumor, cardioprotective, antimicrobial, and immunoenhancing properties. The fungus also demonstrates potential in bioremediation and lignocellulose degradation through production of various enzymes.

Objective

To perform whole genome sequencing and comprehensive annotation of Trametes sanguinea ZHSJ strain isolated from chestnut tree wood. The study aimed to provide genomic and transcriptomic data with functional annotations to enable further research into medically important genes and biosynthetic pathways.

Results

The T. sanguinea ZHSJ genome is 41.3243 Mb with 135 contigs and N50 length of 2.8138 Mb. A total of 10,886 genes were annotated from genome prediction, with transcriptome analysis revealing 11,861 genes and 10,507 genes successfully annotated across databases. Denovo prediction identified 12,268 coding genes, and SSR analysis detected 1,242 microsatellites with 707 trinucleotide repeat motifs being most abundant.

Conclusion

Complete genome sequencing and annotation of T. sanguinea ZHSJ provides valuable genomic resources for identifying genes responsible for medicinal compound production. These data enable future research into biosynthetic pathways and genetic engineering for industrial production of pharmaceutically important compounds with antitumor, anti-inflammatory, and antimicrobial properties.
  • Published in:Scientific Data,
  • Study Type:Genomic Database/Sequencing Study,
  • Source: 10.1038/s41597-025-05798-9; PMID: 40841404
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