Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl2 from a Marine-Derived Fungus Pestalotiopsis sp. Z233
- Author: mycolabadmin
- 2013-08-02
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Summary
This research discovered two new natural compounds produced by marine fungi when exposed to copper stress. These compounds showed promising ability to inhibit tyrosinase, an enzyme involved in skin pigmentation. This discovery could lead to new treatments for skin conditions involving excess pigmentation.
Impacts on everyday life:
• Potential development of new skin whitening or anti-pigmentation treatments
• Demonstrates new ways to discover natural compounds for medical use
• Advances understanding of how organisms adapt to environmental stress
• Could lead to more environmentally friendly production of therapeutic compounds
Background
Marine-derived fungi, living in stressful habitats, are promising sources of biologically active compounds due to their unique environmental conditions including pH, temperature, pressure, oxygen, light, nutrients and salinity. The genus Pestalotiopsis is known for extensive distribution and wide genetic, biological and chemical diversity. Tyrosinase inhibitors can be clinically useful for treating dermatological disorders associated with melanin hyperpigmentation.
Objective
To investigate novel sesquiterpenes produced as stress metabolites in cultured mycelia of Pestalotiopsis sp. Z233 (isolated from algae Sargassum horneri) in response to abiotic stress elicitation by CuCl2, and evaluate their tyrosinase inhibitory activities.
Results
Two new sesquiterpenes were isolated: 1β,5α,6α,14-tetraacetoxy-9α-benzoyloxy-7βH-eudesman-2β,11-diol (1) and 4α,5α-diacetoxy-9α-benzoyloxy-7βH-eudesman-1β,2β,11,14-tetraol (2). These compounds showed tyrosinase inhibitory activities with IC50 values of 14.8 µM and 22.3 µM respectively, compared to kojic acid standard (IC50 = 21.2 µM).
Conclusion
Two novel sesquiterpenes with eudesmane skeleton were successfully produced through metal stress elicitation of marine fungi, exhibiting potent tyrosinase inhibitory activities. This demonstrates that metal stress elicitation on marine fungi is a promising strategy for discovering new bioactive natural compounds.
- Published in:Marine Drugs,
- Study Type:Laboratory Research,
- Source: 10.3390/md11082713