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The Mushroom Agaricus Blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation Through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation

Summary

This research examines how the medicinal mushroom Agaricus blazei Murill (AbM) can help fight various diseases by boosting and balancing the immune system. The mushroom contains natural compounds that stimulate immune cells to better fight cancer, infections, and reduce allergic reactions and inflammation. Impact on everyday life: • Could provide a natural supplement to help prevent and treat various diseases • May help reduce allergy symptoms and inflammation without serious side effects • Shows potential as complementary treatment alongside conventional cancer therapies • Offers a safe way to enhance the body’s natural immune defenses • Could help reduce dependence on conventional anti-inflammatory medications

Background

Agaricus blazei Murill (AbM) is an edible medicinal mushroom from the Brazilian rain forest traditionally used against cancer and various diseases. It contains immunomodulating substances like β-glucans and proteoglycans that interact with immune cell receptors. The mushroom has shown antitumor, anti-infection and antiallergic properties in various studies.

Objective

To examine the scientific evidence behind the traditional medicinal uses of Agaricus blazei Murill and understand its mechanisms of action through immune system modulation.

Results

The AbM extract showed significant protective effects against bacterial sepsis in mice and reduced IgE-mediated allergic responses. In human studies, it demonstrated anti-inflammatory properties by reducing pro-inflammatory cytokines in inflammatory bowel disease patients. The mushroom was found to stimulate innate immune cells and help normalize Th1/Th2 immune balance. No toxicity was observed in safety studies.

Conclusion

Agaricus blazei Murill shows therapeutic potential for multiple diseases including cancer, infections, allergies and inflammatory conditions through its broad modulation of innate immunity and correction of Th1/Th2 imbalances. The mushroom’s anti-inflammatory properties may contribute to its various beneficial effects. AbM extract shows promise both as a preventive agent and as complementary treatment for serious diseases.
  • Published in:Advances in Pharmacological Sciences,
  • Study Type:Review,
  • Source: 10.1155/2011/157015
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