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The Inhibitory Effects of Cordyceps militaris ARA301 Extract on Lipopolysaccharide-Induced Lung Injury in vivo

Summary

Researchers tested a mushroom extract from Cordyceps militaris to see if it could protect mice from lung injury caused by bacterial toxins. The extract successfully reduced inflammation, prevented excessive mucus production, and decreased immune cell buildup in the lungs. These findings suggest that this mushroom extract could potentially be used as a natural supplement to help prevent respiratory diseases and support lung health.

Background

Lung injury caused by pathogens and inflammatory responses impairs respiratory function and can be life-threatening. Cordyceps militaris has been valued for its anti-inflammatory and immunomodulatory properties. This study investigates whether Cordyceps militaris ARA301 extract (CME) can prevent lipopolysaccharide (LPS)-induced acute lung injury.

Objective

To establish a mouse model of LPS-induced lung injury from Klebsiella pneumoniae and evaluate whether oral CME administration can prevent lung injury through suppression of immune cell infiltration, inflammatory responses, and tissue damage.

Results

CME administration significantly inhibited immune cell infiltration, tissue fibrosis, and mucus deposition in lung tissue. CME suppressed expression of MUC5AC, iNOS, and COX-2, and reduced production of IL-1β, IL-6, TNF-α, and CXCL1 in BALF. CME also decreased immune cell recruitment and suppressed NF-κB pathway activation in vitro through inhibition of p65, IκBα, and IKKα phosphorylation.

Conclusion

CME effectively alleviates LPS-induced lung injury by suppressing inflammatory responses, reducing immune cell recruitment, and modulating the NF-κB signaling pathway. These findings suggest CME has significant potential as a functional health supplement for respiratory disease prevention.
  • Published in:Journal of Microbiology and Biotechnology,
  • Study Type:In vivo and in vitro experimental study,
  • Source: PMID: 40081908, DOI: 10.4014/jmb.2412.12043
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