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The Genus Cordyceps Sensu Lato: Their Chemical Constituents, Biological Activities, and Therapeutic Effects on Air Pollutants Related to Lung and Vascular Diseases

Summary

Cordyceps mushrooms have been used in traditional Chinese medicine for centuries and are now being studied scientifically for their potential health benefits. These mushrooms contain powerful compounds that may help protect our lungs from air pollution effects and support heart health. Recent clinical studies show promising results for treating conditions like COPD, asthma, and even improving athletic performance in healthy people.

Background

Air pollutants significantly contribute to exacerbation of respiratory, cardiopulmonary, and skin diseases in East Asia. Cordyceps species have been integral to traditional Chinese medicine for centuries and contain bioactive compounds with documented physiological effects.

Objective

To review the chemical constituents, biological activities, and therapeutic potential of Cordyceps species in managing air pollutant-related respiratory and vascular diseases through examination of preclinical and clinical studies.

Results

Cordyceps species demonstrate immunoprotective, antimicrobial, antiviral, anticancer, anti-inflammatory, and antioxidant properties. Clinical trials show improvements in COPD lung function, asthma symptoms, respiratory function, exercise performance, and vascular health through modulation of key molecular pathways.

Conclusion

Cordyceps species and their bioactive derivatives show promise for clinical application in managing air pollutant-related respiratory and vascular diseases, supported by both preclinical and clinical evidence, though further standardization and clinical data are necessary.
  • Published in:Life (Basel),
  • Study Type:Review,
  • Source: PMID: 40566586
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