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The Effect of Ganoderma Lucidum Spore Oil in Early Skin Wound Healing: Interactions of Skin Microbiota and Inflammation

Summary

This research investigated how oil extracted from Ganoderma lucidum mushroom spores can help heal burn wounds faster. The study found that this natural compound helps wounds heal by managing beneficial bacteria on the skin and reducing inflammation. This discovery could lead to better treatments for burn injuries. Impacts on everyday life: • Could provide a natural alternative to antibiotics for treating burns • May reduce scarring from burn injuries • Could lead to faster healing times for burn wounds • Potential for developing new wound-healing products • May reduce the need for long-term wound care

Background

Skin is the body’s largest and most exposed organ, serving as the first line of immunological defense against external threats. Burns damage the skin extensively, with thermal burns accounting for approximately 80% of reported burn injuries. Around 180,000 deaths annually are caused by burns, mostly in low and middle-income countries. Current treatments often rely on antibiotics, leading to increased microbial drug resistance and poor treatment efficacy.

Objective

To evaluate the effect of Ganoderma lucidum spore oil (GLSO) on skin burn wound healing and investigate the underlying mechanisms, particularly focusing on its interactions with skin microbiota and inflammation responses.

Results

GLSO significantly accelerated the process of skin wound healing and regulated the levels of gram-negative and gram-positive bacteria. The treatment reduced LPS and TLR4 levels, along with other related inflammatory cytokines. In the pseudo-germfree mice model, GLSO showed significant acceleration of skin wound healing compared to antibiotic treatment. The study found that GLSO downregulated inflammation by regulating skin microbiota to accelerate skin wound healing.

Conclusion

GLSO effectively accelerates skin wound healing by down-regulating inflammation through regulation of skin microbiota. The study identifies GLSO as an effective accelerant in skin wound healing in a burn wound model, suggesting its potential for clinical application in treating burn injuries.
  • Published in:Aging (Albany NY),
  • Study Type:Experimental Animal Study,
  • Source: 10.18632/aging.103412
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