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The Antioxidant and Anti-Aging Effects of Acetylated Mycelia Polysaccharides from Pleurotus djamor

Summary

This research examined how modified compounds from the mushroom Pleurotus djamor could help combat aging and its related health issues. Scientists found that these mushroom-derived compounds had powerful antioxidant properties and could protect various organs from age-related damage. The findings have important implications for everyday life: • Could be developed into natural dietary supplements to help prevent aging • Offers a safer alternative to synthetic antioxidants that may have toxic effects • May help protect vital organs like the liver, kidneys and brain from age-related deterioration • Shows potential for development into functional foods that promote healthy aging • Demonstrates how natural mushroom compounds can be modified to enhance their health benefits

Background

Aging is an inevitable physiological process that can lead to gradual loss of body function and increased risk of age-related diseases like diabetes, cognitive impairment, cancer, liver damage, Parkinson’s disease, and atherosclerosis. D-galactose can induce accelerated aging in mammals through oxidative stress and free radical production. While synthetic antioxidants exist, they can be toxic, creating a need for natural alternatives. Mushroom polysaccharides have shown promise as natural antioxidants with various biological functions.

Objective

To prepare acetylated mycelia polysaccharides (AMPS) from Pleurotus djamor and investigate their antioxidant and anti-aging effects in D-galactose-induced aging mice. The study aimed to optimize the acetylation process and characterize the resulting compounds while evaluating their potential therapeutic benefits.

Results

The optimal acetylation produced AMPS with a substitution degree of 0.54 ± 0.04. AMPS showed strong antioxidant activity in vitro and significant anti-aging effects in vivo. Treatment with AMPS elevated antioxidant enzyme activities (SOD, GSH-Px, CAT), reduced lipid peroxidation markers (MDA, LPO), improved serum biochemical indices, and enhanced immunological activity. Histopathological observations showed AMPS could reduce tissue damage in liver, kidney and brain caused by D-galactose-induced aging.

Conclusion

AMPS from P. djamor demonstrated potent antioxidant and anti-aging properties both in vitro and in vivo. The acetylation modification successfully enhanced the biological activity of the polysaccharides. The results suggest AMPS could be used as a dietary supplement and functional food for preventing aging and age-related diseases.
  • Published in:Molecules,
  • Study Type:Experimental Study,
  • Source: 10.3390/molecules24152698
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